The invention discloses a heat radiation system for a universal power amplifier module. The heat radiation system comprises a universal power amplifier, a lower-layer water channel, housing heat radiation iron sheets, two water flow circulation devices and a housing, wherein the universal power amplifier is covered and wrapped with the housing, the housing heat radiation iron sheets are arranged on the surface of the housing, and are vertically and neatly arranged on the surface of the housing, and gaps are formed between adjacent housing heat radiation iron sheets; the surface of the housing is covered with the lower-layer water channel, uniform bumps are formed on the lower side of the lower-layer water channel, and the parts of the bumps are matched with the gaps between the housing heat radiation iron sheets; an upper-layer water channel is arranged on the upper side of the lower-layer water channel, and the surface of the lower-layer water channel is covered with the upper-layer water channel; the two ends of the upper-layer water channel and lower-layer water channel are correspondingly communicated through the water flow circulation devices respectively. According to the heat radiation system, by virtue of very high specific heat capacity of water, heat stays for a short time in the water, so that heat around the universal power amplifier can be conveniently transmitted to a large space, and heat radiation of the power amplifier is facilitated.