The invention relates to the technical field of machining centers, in particular to a low-noise vertical machining center. The low-noise vertical machining center comprises a main machine and a protective frame. The outer side of the main machine is covered by the protective frame. The main machine comprises a machine frame, a workbench, a machining portion and a tool rest, wherein the workbench, the machining portion and the tool rest are installed on the machine frame. The machining portion is hung above the workbench in a lifting mode. The tool rest is located on one side of the machining portion. The inner wall of the protective frame is provided with an acoustic panel. The tool rest is provided with a silencer. The position, provided with the workbench, of the machine frame is provided with a damping belt. Noise produced by the machining portion in the machining process is isolated through the acoustic panel, the noise is effectively reduced when a tool of the tool rest is replaced through the silencer, vibration of the workbench is relieved through the damping belt in the machining process of the machining portion, a protection effect can be effectively achieved, and meanwhile noise brought by machining can be effectively reduced.