The invention discloses a damp-proof drug packaging bottle. The damp-proof drug packaging bottle comprises a bottle body and a bottle cap. The bottle cap is in threaded connection with the top of the bottle body. A rubber sealing pad is arranged on the inner wall of the bottom of the bottle cap. A first switching group and a second switching group are arranged on one side of the bottle body. The first switching group is located above the space of the second switching group, and the first switching group and the second switching group are the same in structure and each comprise a switching piece and a baffle. A set of first holes are formed in the horizontal direction of one side of the bottle body. Grooves are formed in the vertical directions of the inner walls of the first holes. According to the damp-proof drug packaging bottle, tablets which need to be taken out and tablets which do not need to be taken out are separated at first, and then the tablets which need to be taken out are taken out from the bottle body after the tablets which do not need to be taken out are continuously sealed, so that tablets which need to be stored in the bottle body do not make contact with the outside air when taken, the damp-proof effect is well achieved, and the using requirement by people in production and living is met.