The invention discloses a full-automatic precise positioning system of a superconducting proton acceleration degrader. The full-automatic precise positioning system comprises a steel structure frame, wherein the steel structure frame comprises a rectangular bottom frame and a rectangular top frame which are opposite to each other; the rectangular bottom frame is fixedly connected with the rectangular top frame through four stand columns; an engineering cylinder is mounted and fixed on the rectangular bottom frame; a lifting platform is horizontally mounted between the four stand columns; two fixed rods are horizontally fixed between a left frame and a right frame of the rectangular top frame; two guide brackets are fixed on the bottom surfaces of a front frame and a rear frame of the rectangular top frame; guide holes are formed in the guide brackets; four locking and hanging plates are uniformly distributed on the surface of the lifting platform; two guide pins are fixed on the surface of the lifting platform; the guide pins are matched with the guide holes. Through the full-automatic precise positioning system, the superconducting proton acceleration degrader is precisely positioned; the damage of radiation to the human body in the maintenance process of a superconducting proton acceleration treatment system is reduced; the maintenance efficiency is improved.