The invention provides a method and apparatus for optimizing the information interaction topology of unmanned aerial vehicle-manned vehicle formation. The method comprises the following steps: in the case of a communication fault of unmanned aerial vehicle-manned vehicle formation, obtaining the type of the communication fault; deleting a communication fault arc or a communication fault node in a formation communication graph according to the type of the communication fault to obtain an optimized formation communication graph; if the in-degree of a corresponding node of an unmanned aerial vehicle in a two-dimensional optimal persistence graph is 0, determining that the two-dimensional optimal persistence graph is the optimized information interaction topologyof the unmanned aerial vehicle-manned vehicle formation; and otherwise, adjusting the two-dimensional optimal persistence graph through an arc reverse operation, and determining that the adjusted two-dimensional optimal persistence graph is the optimized information interaction topology of the unmanned aerial vehicle-manned vehicle formation. By adoption of the method and apparatus provided by the invention, the information interaction topology can be quickly optimized after the communication fault of two-dimensional persistent formation formed by unmanned aerial vehicles-manned vehicles so as to avoid a collision accident and restore the formation.