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发明公开
CN107141352A SeZn7MT3的组成、制备方法及其在防治阿尔茨海默症中的应用 审中-实审

SeZn<base:Sub>7</base:Sub>MT3的组成、制备方法及其在防治阿尔茨海默症中的应用
摘要：
本发明属于生物医药技术领域，发明了SeZn7MT3创新组成的金属蛋白及其高效制备方法，通过生物工程技术与化学合成相结合的方法，能高效地制备SeZn7MT3。本发明研究表明，SeZn7MT3可以改善阿尔兹海默症模型鼠的认知和记忆功能，调控和改善AD大脑海马体细胞形态，抑制神经细胞凋亡，抑制淀粉样蛋白沉积，能有效地阻止老年痴呆症病情发展。因此，SeZn7MT3在防治阿尔茨海默症方面有重要应用前景。
摘要（英）：

The invention belongs to the technical field of biological medicine, and discloses SeZn7MT3 innovatively constituent metal protein and a high-efficiency preparation method thereof, and through a biotechnology and chemical synthesis combined method, SeZn7MT3 can be efficiently prepared. Shown by study of the invention, the SeZn7MT3 can improve the cognition and memory functions of a model rat with Alzheimer's disease, regulate and improve the morphology of AD brain hippocampus cells, inhibit nerve cell apoptosis, inhibit amyloid deposit, and effectively prevent the development of Alzheimer's disease. Consequently, the SeZn7MT3 has important application prospects in preventing and treating the Alzheimer's disease.

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