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CN107141353A 分泌的aP2及其抑制方法 无效 - 撤回

分泌的aP2及其抑制方法
摘要：
一种减少以异常升高的循环中aP2为表征的临床病症的症状方法，该方法通过给予患者一种分泌的aP2的抑制剂，aP2的分泌抑制剂，或者一种血清aP2封堵剂来进行。例如，随着这种抑制剂或者药剂的给药减少葡萄糖不耐性。典型的组合物抑制aP2的抑制细胞的分泌或者结合到流通的aP2，从而减少血中或者血清中aP2的水平或者活性。
摘要（英）：

A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.

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