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发明授权
CN107158408B 一种具有上转换成像功能的药物与基因传输体系 失效 - 权利终止

一种具有上转换成像功能的药物与基因传输体系
摘要：
本发明提供了一种具有上转换成像功能的药物与基因传输体系，具有以下组成：UCNPs@mSiO2‑SS‑H2A；其中，所述药物与基因传输体系连接的靶基因为抑癌基因如抑癌基因p53。本发明的UCNPs@mSiO2‑SS‑H2A杂合基因载体材料，选择对小牛胸腺组蛋白H2A进行修饰，使该体系能够作为基因载体，提升基因负载能力、降低载体毒性并兼顾靶向配体的作用；其次，本发明的UCNPs@mSiO2‑SS‑H2A可以在同时传递药物与基因的过程中，具有上转换成像示踪功能；最后本发明的UCNPs@mSiO2‑SS‑H2A杂合基因载体材料能够起到化学治疗与基因治疗的协同效应。本发明的基因载体材料，基因转染效率高、可视、安全无毒，为具有靶向核定位能力的诊疗载体，将为恶性肿瘤的治疗提供新的治疗方法和手段。
摘要（英）：

The invention provides a drug with an upconversion imaging function and a gene transmission system. The drug has the following composition: UCNPs@mSiO2-SS-H2A, wherein a target gene connecting the drug and the gene transmission system is a cancer-inhibiting gene, for example, a cancer-inhibiting gene p53. The UCNPs@mSiO2-SS-H2A provided by the invention hybridizes a gene carrier material and selectively modifies calf thymus histone H2A, so that the system can be used as a gene carrier to enhance the gene loading capacity, reduce the toxicity of the carrier and give consideration to the action of a target ligand; secondly, the UCNPs@mSiO2-SS-H2A provided by the invention has an upconversion imaging tacking function in a process of transferring the drug and the gene; and finally, the UCNPs@mSiO2-SS-H2A hybridized gene carrier material plays a synergistic role of chemical treatment and gene therapy. The gene carrier material provided by the invention is high in gene transfection efficiency, visible and safe and non-toxic and is a diagnosis and treat carrier with targeted nuclear localization capacity, thereby providing a novel treatment method and means for treating malignant tumors.

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