The invention discloses a multi-axis numerical control machine. The multi-axis numerical control machine can drive a workpiece clamping mechanism to axially move along an X axis, a Y axis and a Z axis and rotate around the Z axis and the Y axis. A movement bracket comprises a first sliding plate body, a second sliding plate body and a third sliding plate body; through nuts, the first sliding plate body is connected with a Z axial lead screw which is installed on a rack, arranged in the axial direction of the Z axis and can rotate around the axis of the Z axial lead screw; the first sliding plate body is further connected with the rack through a third guide mechanism, and the guiding direction of the third guide mechanism extends in the axis direction of the Z axis; and the first sliding plate body is fixedly connected with a movement piece in the third guide mechanism which comprises a Z axial guide rail or a Z axial guide rod which is installed on the rack and arranged in the axis direction of the Z axis, and the movement piece of the third guide mechanism is a Z axial sliding block or a sliding sleeve which is matched with the Z axial guide rail or the Z axial guide rod.