The invention discloses a sealing cabin for dangerous goods transportation and a transportation method using the sealing cabin. The sealing cabin comprises a cabin body, a first cabin door, a second cabin door and an air exhaust connector arranged on the cabin body, and the first cabin door and the second cabin door are oppositely arranged and are arranged on the cabin body in a movable opening and closing manner; the first cabin door is provided with a hanger rope sealing device which is communicated with the interior of the cabin body and allows a hanger rope to pass through; and the air exhaust connector is communicated with the interior of the cabin body, the hanger rope sealing device is communicated with the air exhaust connector through the interior of the cabin body, and an air output runner is formed. By means of the sealing cabin, when hazardous articles such as high-radioactivity and dangerous biochemistry equipment or containers are transported, under the condition that the gas tightness is guaranteed in the whole process, coherent object hoisting transportation is carried out, the step of operating the dangerous equipment or containers in the transportation process can be omitted, personnel contact can be reduced, and the dangerousness is reduced.