The invention discloses an anti-seismic support installation structure on the two sides of wall-through holes. The anti-seismic support installation structure comprises a first double-sided channel steel, a second double-sided channel steel, a first single-sided channel steel, a second single-sided channel steel, a third single-sided channel steel, a fourth single-sided channel steel and pipe clamps, wherein the first double-sided channel steel and the second double-sided channel steel are arranged on the top of a wall surface, the first single-sided channel steel and the second single-sided channel steel are arranged at the bottom of the wall surface, the third single-sided channel steel is connected with the end part of one side of the first double-sided channel steel and the end part of one side of the second double-sided channel steel separately, the fourth single-sided channel steel is connected with the end part of the other side of the first double-sided channel steel and the end part of the other side of the second double-sided channel steel separately, the pipe clamps are arranged below the third single-sided channel steel and the fourth single-sided channel steel through threaded rods and pipe clamp buckle pads, and the first double-sided channel steel and the second double-sided channel steel are connected with the first single-sided channel steel and the second single-sided channel steel through connecting devices respectively. Compared with the prior art, the anti-seismic support installation structure can effectively deal with impact force from all directions when an earthquake occurs, and the structural strength of the anti-seismic support installation structure is better.