The invention discloses a refrigerator with a self-cleaning function. The refrigerator comprises a hollow shell body and an interlayer partitioning the shell body into a refrigerating chamber and a freezing chamber; the shell is internally provided with a pipe, the pipe is connected with a water storage tank through a high-pressure pump, the refrigerating chamber and the freezing chamber are internally provided with a plurality of spray nozzles correspondingly, water inlets of the spray nozzles communicate with the pipe, and the pipe is furthermore internally provided with a heating resistance wire; and the interlayer is arranged to be of a hollow structure and is internally provided with a water collection tank capable of being drawn out. According to the refrigerator with the self-cleaning function, a high-pressure water flow is utilized to clean the freezing chamber and the refrigerating chamber, and dirt in gaps can be effectively cleared; the heating resistance wire is arranged, the water flow in the pipe is heated, the spray nozzles are prevented from being iced and blocked, hot water can dissolve frozen frost inside the freezing chamber, and the cleaning effect is good; and the water collection tank is arranged in the interlayer, when cleaning is performed, the water collection tank is drawn out, sewage for cleaning the refrigerating chamber can directly flow into the water collection tank, and the sewage is prevented from contaminating the refrigerator shell body and the ground.