The invention provides an isolation switch, and aims to solve the problem of high probability of contamination to a static contact and a movable contact which are exposed in the air. The isolation switch comprises a sealed shell; the static contact and the movable contact are arranged in the sealed shell; a transmission rod connected with the movable contact and used for driving the movable contact to act is assembled on the sealed shell in a sealing manner; and the isolation switch also comprises a static end outlet wire and a movable end outlet wire which are conductively connected with the static contact and the movable contact respectively and are arranged on the sealed shell in a sealing manner. The movable contact and the static contact are sealed in the sealed shell to be isolated from air, so that the contacts are not affected by dirt, rain and dew, moist and other environment factors; the transmission rod can drive the movable contact to act to complete switch on and switch off; the static end outlet wire is connected with the static contact while the movable end outlet wire is connected with the movable contact; and the transmission rod, the static end outlet wire, the movable end outlet wire and the sealed shell are all assembled in a sealing manner, so that the airtightness of the sealed shell can be ensured.