The invention discloses a hydrodesulfurization method of catalytically cracked gasoline. The hydrodesulfurization method includes that a fixed-bed reactor is adopted, a catalyst takes alumina as a carrier, and active ingredients are cobalt oxide and nickel oxide; reaction process conditions include that reaction temperature is 190-310 DEG C, reaction pressure 1.3-2.6MPa, volume space velocity is 1.3-3.5h-1, and hydrogen-oil volume ratio is 180-400:1. The hydrodesulfurization method is mild in the process conditions, high in adaptability to different raw materials, low in octane number loss and high in desulfurization rate.