The invention provides a refrigerator with a food vacuum pre-cooling chamber. The refrigerator is internally provided with a vacuum pre-cooling chamber, and the vacuum pre-cooling room and a refrigerating chamber are relatively independent and sealed; a compressor compartment is internally provided with a vacuum pump of which an air inlet is connected to an air extraction pipe, and the other end of the air extraction pipe communicates with the vacuum pre-cooling chamber; the air extraction pipe is provided with a check valve; the vacuum pre-cooling chamber is internally provided with a pressure sensor used for measuring a pressure value in the vacuum pre-cooling chamber in real time and feeding back the pressure value to a main control panel of the refrigerator; and the vacuum pre-cooling chamber is also provided with an exhaust valve, and the top of the vacuum pre-cooling chamber is provided with a vapor condenser of which the bottom is connected to a drainage device. The refrigerator provided by the invention has the advantages of novel structure, rational design and high practicability, and the respiration intensity of food, especially fruits and vegetables, can be reduced greatly; and the shelf life of the food is prolonged, and the energy consumption of the refrigerator is reduced.