The invention relates to a manufacturing system and a manufacturing process for a stone-like ceramic tile with a vivid stone imitation effect. The manufacturing system comprises a material distributing device, a pressing device, a biscuiting device, a bottom-layer glaze pouring device, an ink-jet printing device, a surface layer glaze spraying device, a firing device and a cutting polishing device which are sequentially connected through a conveyor belt. Compared with the prior art, the manufacturing system has the advantages that processes of pouring glaze, spraying ink and spraying glaze are adopted to sequentially prepare a glaze bottom layer, a color layer with the stone-like effect and a glaze protective surface layer on a brick blank surface layer, so that the problem that insufficient color and luster or over-burning is caused as an ink-jet material is affected by a temperature in a firing process is overcome; and meanwhile, the glaze protective surface layer can protect stability of pattern color of ink-jet 3D printing, so that a final product has a relatively fine condition in aspect of external perception and interior quality.