The invention discloses a method for efficient separation and recycling of 5,10-alpha epoxy isomer in telapristone synthesis. A 5,10-alpha epoxide is a key intermediate in a telapristone synthesis process, and preparation of a high-purity 5,10-alpha epoxy isomer is the key in control of a whole quality system. The 5,10-alpha isomer is efficiently separated by means of solvent pulping for the first time, the content reaches 99%, and the yield is up to 65%. More significantly, a mixture of two epoxy isomers in mother solution after separation of the 5,10-alpha epoxy isomer can be subjected to reduction and elimination reaction to return to a raw material 17beta-cyano-17alpha-trimethylsiloxy-13beta-methyl sterane-5,9-diene-3,3-(ethylenedioxy). The method is remarkable in improvement of raw material utilization efficiency and has a large-scale application prospect.