The invention relates to the technical field of coal mines, in particular to a multi-hazard comprehensive control method capable of meeting high-pressure hydraulic cutting, fracturing and injection requirements. The method comprises the first step of drilling construction, the second step of hydraulic cutting, the third step of hole sealing, the fourth step of hydraulic fracturing and the fifth step of liquid injection. By means of the method, comprehensive treatment of hazards, such as rock burst, coal dust and hydrogen sulfide, can be achieved, a traditional method that a single hazard is treated in a single mode is broken through, comprehensive treatment of various hazards of the coal mines is achieved, a lot of capital for single hazard treatment is saved, and the hazard treatment efficiency of the coal mines is improved; equipment and material investment cost can be reduced, control of various hazards, such as rock burst, coal dust and hydrogen sulfide, can be achieved by drilling only one hole, extra equipment and materials do not need to be purchased, and no other investment exists.