The invention discloses a high-temperature air burning organization optimization method based on a response surface method. The method comprises the steps that 1, a plurality of burning organization factors for performing high-temperature air burning of a burning furnace are determined; 2, according to the burning organization factors determined in the step 1, burning organization factor parameter combinations for high-temperature air burning organization optimization are determined through the response surface method; 3, the corresponding factors of the burning furnace are adjusted according to the burning organization factor parameter combinations in the step 2. The high-temperature air burning organization optimization method has the advantages that U-shaped radiant tubes are used as study objects, a high-temperature air burning technology is applied, and a numerical simulation method is adopted to obtain NO discharge amount, the influence of the three factors combustion air preheating temperature, excess air coefficients and primary and secondary air grading ratio to the NO discharge amount is optimized through the response surface method, and a scientific basis is provided for burning organization determination in actual industrial production.