The invention discloses a mix proportion design method for a high-friction bituminous mixture. The method comprises the following steps: I, determining the structure depth of the high-friction bituminous mixture to be designed; II, selecting coarse aggregate with good anti-slide performance; III, designing the graduation, and blending to form mineral aggregate; IV, according to an anti-slide performance pre-estimating model of the bituminous mixture, pre-estimating the structure depth of the high-friction bituminous mixture, if the structure depth of the high-friction bituminous mixture satisfies the request, preparing the bituminous mixture; otherwise returning to the step III; V, performing an indoor long-term anti-slide performance test to the bituminous mixture, if the bituminous mixture satisfies the request, turning to the step VI; otherwise returning to the step III; and VI, performing a pavement performance test to the bituminous mixture, if the bituminous mixture satisfies the request, to obtain the high-friction bituminous mixture; otherwise, using the bitumen with the higher level. The method is capable of, through the structure depth pre-estimating model, pre-estimating the anti-slide performance of the bituminous mixture. Compared with a traditional method, the method has the stronger intentionality, and the designed bituminous mixture has the good anti-slide performance.