The invention relates to a falling-prevention connection method of an irregularly-shaped wire. Wires are combined by anchoring of a strain clamp and crimping of an aluminum pipe, an anchor and a steel core of the wires are firmly connected by an anchored steel core, and the steel core of the wires is held by a combined force of the anchored steel core and the anchor. The falling-prevention connection method has the advantages that the defect of line slipping or falling of an existing conventional strain clamp due to a friction force smaller than a pull force is overcome, line slipping or falling caused by that the friction force of a wedge core of the strain clamp on an insulation layer of a wire is smaller than a pull force of an overhead wire applied to the wedge core can be prevented, and a potential risk is reduced to the greatest extent.