The invention particularly discloses a rock-soil body side slope erosion resistance and ecological restoration protection method. While a rock-soil body side slope is reinforced through pile columns, soil block partition plates, a plant seed carrying layer and a water seepage pipe net, soil fixation and water retention vegetation is made to stably grow on the side slope, and scour erosion of rainwater over the side slope is overcome; and water supplying can be simultaneously conducted on the vegetation through spray irrigation and water seepage irrigation, mass production can be conducted on the pile columns, the soil block partition plates, the plant seed carrying layer and the water seepage pipe net in large scale and standardized modes, the cost of equipment for side slope transformation and green planting is reduced, and the method can be widely suitable for green planting requirements of various side slope zones. Through the method, the poor soil fixation and water storage capacities of the side slope can be improved, the stable fixing effect can be achieved for the vegetation growing on the side slope, and the stable growing and surviving capacities of the vegetation are improved.