The invention discloses a toadstool entity disease and insect pest prevention and control method, and belongs to the technical field of edible fungus disease and insect pest prevention and control. According to the toadstool entity disease and insect pest prevention and control method, place cleaning and post-planting prevention management are mainly adopted; on one hand, fallen leaves among birch groves are adopted and incinerated into ashes on the basis of musk shells and rhizoma zingiberis, the ashes are mixed with cultivation soil for sterilizing the soil, compared with an existing medicament soil disinfection method, soil harmful chemical substance residues are avoided, and the method is more environmentally friendly; on the other hand, on the basis of the growth characteristic of toadstool entities, timed watering and cooling are adopted, a low-temperature disease and insect pest prevention medicine solution is sprayed regularly, the toadstool entity disease and insect pest morbidity is lowered, toadstool grows well, the weight of the sporocarp is increased, no any pesticide residues exist, and the eating safety is ensured.