The invention discloses a high copper-to-nickel-ratio mineral flotation method. The high copper-to-nickel-ratio mineral flotation method comprises the following steps of A, pretreatment of raw materials, and A.2, mineral grinding for grading; A.2.1, primary mineral grinding; A.3, powder adding, slurry mixing and stirring; B.1, the primary rough concentration process; B.2, primary first-time concentrating; B.3, primary second-time concentrating; C, the secondary rough concentration process, and C.1, secondary mineral grinding; C.3, the secondary rough concentration process; C.4, secondary one-time concentrating; C.5, secondary second-time concentrating; C.6, secondary one-time scavenging; C.7, secondary second-time scavenging; and D.1, graded regrinding of part products in the secondary process. According to the high copper-to-nickel-ratio mineral flotation method, the mineral processing process is adopted, the fine grinding and concentrating operation efficiency is strengthened, and the requirement for quick selection and early collecting of copper nickel is met; after implementation, the copper recovering rate of high copper-to-nickel-ratio sulfide copper-nickel mineral is improved by about 1% or more, the copper concentrate grade is improved by about 0.5%, and the copper metal output amount is obviously improved. What's more, an economical and applicable beneficiation method is provided for sorting same-class joined and accompanied mineral, and the high application and popularization value is achieved.