The invention discloses a pre-emulsified powder syrup of hydrophobic and oleophobic powder, and a preparation method and application thereof. The pre-emulsified powder syrup of the hydrophobic and oleophobic powder is prepared from the following components in parts by weight: 10 to 70 parts of hydrophobic and oleophobic powder, 10 to 40 parts of grease, 0.5 to 8 parts of dispersing agent, 0.1 to 5 parts of thickening stabilizer, and 8 to 50 parts of moisturizing agent, the defects of the application limit of the hydrophobic and oleophobic powder can be overcome, the pre-emulsified powder syrup has the advantages of easiness in dispersion, uneasiness in powder leakage and color drifting, good compatibility, good stability, good makeup maintaining performance and the like in a cosmetics formula, and does not produce dust pollution in the application process.