The invention discloses an inhalable aerosol, a raw material composition thereof and preparation methods thereof. The raw material composition of the inhalable aerosol, disclosed by the invention, contains a medicinal active component and a propellant, wherein the medicinal active component contains a long-acting beta-receptor agonist and glucocorticoid; the propellant comprises tetrafluoroethane. The inhalable aerosol disclosed by the invention contains the raw material composition, a pressure container and a valve system. The inhalable aerosol uses the tetrafluoroethane as the propellant; during preparation, medicine particles are prepared by a supercritical method and a spray drying method, so that the inhalable aerosol with uniform particle distribution can be obtained; in the preparation method, the loss is low; in addition, the single dose of the inhalable aerosol is adjusted, so that the greenhouse gas amount of a product is effectively reduced.