The invention provides a multi-purpose grounding clamp. The multi-purpose grounding clamp comprises a U-shaped body, a grounding connector and two cable clamping plates, wherein the grounding connector is arranged at a sealing end of the U-shaped body, the two cable clamping plates are symmetrically arranged in the U-shaped body, bottom ends of the two clamping plates are respectively hinged with the sealing end of the U-shaped body, a spring sheet is arranged between an upper part of each cable clamping plate and a leg of the U-shaped body at the same side, and a plurality of semi-arc grooves with unequal diameters are formed in an inner side of each cable clamping plate. The multi-purpose grounding clamp has the advantage of high working efficiency, is firm to fix and convenient to use and is applicable to different line diameters.