The invention belongs to the technical field of traditional Chinese medicine formula granules and particularly relates to traditional Chinese medicine formula granules for treating toothache caused by internal heat and a preparation method of the traditional Chinese medicine formula granules. The traditional Chinese medicine formula granules are prepared from active ingredients including radix glycyrrhizae, radix rehmanniae praeparata, mint leaves and pinellia ternata. The preparation method of the traditional Chinese medicine formula granules comprises process steps as follows: supercritical extraction of volatile oil, volatile oil inclusion, extraction, concentration, drying, granulation and the like. The volatile oil is subjected to supercritical extraction and beta-cyclodextrin inclusion, loss of volatile ingredients of medicines in the extraction, drying and granulation processes is avoided, the ingredients of the formula granules prepared with the method keep basically the same as those of a traditional decoction, and the treatment effect is guaranteed. Additionally, volatile oil-beta-cyclodextrin inclusion and extract powder are dried with a static microwave vacuum drier, the yield is increased, the drying process is simpler, and less loss is caused. Auxiliary materials in the formula granules can effectively cover original puckery and pungent flavors of traditional Chinese medicines, the problem of poor taking taste is solved, and compared with externally applied medicines for the oral cavity, the traditional Chinese medicine formula granules are more easily accepted by patients.