The invention discloses an LLM-105 (2,6-diamino-3,5-dinitropyrazine-1-oxide) nitramine derivative and a preparation method thereof. The LLM-105 nitramine derivative is prepared by using 2,6-dimethoxypyrazine as a raw material, and successively performing an oxidizing reaction, a nitration reaction, an amination reaction and a nitration reaction. The invention provides the effective preparation method for the LLM-105 nitramine derivative. Calculation shows that the LLM-105 nitramine derivative has a detonation property higher than that of a precursor LLM-105, and the LLM-105 nitramine derivative has potential application values.