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发明公开
CN107266406A α-吡喃酮类化合物及其药物组合物和其在制药中的应用 无效 - 撤回

α-吡喃酮类化合物及其药物组合物和其在制药中的应用
摘要：
本发明提供α-吡喃酮类化合物，以其为活性成分的药物组合物，以及它们在制备他莫昔芬复敏药物中及其在制备治疗症癌的药物中的应用。以吡喃酮类作为复敏因子在治疗乳腺癌他莫昔芬耐药中的应用。本发明开发了具有同类母核的先导化合物，提供了α-吡喃酮类化合物为乳腺癌传统治疗使用药物他莫昔芬耐药中的用途，可作为药物他莫昔芬治疗过程的复敏因子，而且本发明化合物易合成，成本廉价，副作用小。
摘要（英）：

The invention provides an alpha-pyrone compound, a drug composition adopting the same as active component and applications in preparing tamoxifen resensitization drugs and drugs for treat cancers as well as an application in preparing tamoxifen resistant drugs for treating breast cancer by adopting pyrones as a resensitization factor. The invention develops a leading compound with similar parent nucleus, provides a purpose of the alpha-pyrone compound in preparing the tamoxifen resistant drugs for traditional treatment of the breast cancer, and can be used as the resensitization factor of the tamoxifen drugs in the treatment process; and the compound is easy in synthesis, low in cost and less in side effect.

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