The invention discloses a suction caisson foundation with a grouting device on the side wall. The suction caisson foundation with the grouting device on the side wall comprises a negative pressure cylinder, wherein an opening is formed in the lower end of the negative pressure cylinder, a sealing cover is arranged at the upper end of the negative pressure cylinder, the sealing cover is provided with a cable guide hole, a drainage valve and a lead hole, and the drainage valve and the lead hole communicate with the inner cavity of the negative pressure cylinder; circular ring type grouting pipelines are arranged on the peripheries of the inner wall and the outer wall of the negative pressure cylinder, the circular ring type grouting pipeline are arranged in a layered mode and are mutually independent, the inner wall circular ring type grouting pipelines are connected through inner wall vertical connecting pipes, the upper parts of the inner wall vertical connecting pipes penetrate through the lead hole and are connected with the grouting device; the outer wall circular ring type grouting pipelines are connected through an outer wall vertical connecting pipe; and the inner wall vertical connecting pipes are not provided with grouting holes, the plurality of grouting holes are formed in the circular ring type grouting pipelines, and the grouting pipelines are made of steel and are firmly welded with the inner wall and the outer wall of a negative pressure cylinder body. According to the suction caisson foundation, grouting is carried out on the inner wall and the outer wall of the negative pressure cylinder body, so that the friction resistance between the negative pressure cylinder and soil is increased, and the vertical uplift bearing capacity of the suction caisson foundation is improved.