The invention discloses a double-break vacuum interrupter switching circuit of a vacuum on-load tap changer. The double-break vacuum interrupter switching circuit comprises three phases of full-vacuum interrupter switching circuits and a driving mechanism, wherein each phase of full-vacuum interrupter switching circuit comprises an N tapping side main through-flow switch, an N+1 tapping side main through-flow switch, two transition resistors and two double-break vacuum interrupters. The double-break vacuum interrupter switching circuit has the advantages that: the switching circuit is simplified by replacing four single-break vacuum interrupters in the existing vacuum on-load tap changer with the two double-break vacuum interrupters, such that the switching circuit is simpler, the space occupied by the vacuum interrupters is reduced, the size of a vacuum switching switch can be smaller, the transition circuit becomes simple, and the mechanical failure rate is reduced.