The invention relates to a high voltage supply electric leakage protection method and apparatus. The high voltage supply electric leakage protection method includes the steps: acquiring the leakage current between a high voltage output terminal and a high voltage ground wire terminal; processing the leakage current; determining whether the processed leakage current is greater than the reference current; and controlling an electronic switch to be disconnected, and controlling the high voltage supply to stop working at the same time. The invention also relates to an apparatus. The apparatus includes an electronic switch, a leakage current acquisition circuit, a signal conditioning circuit, an electronic switch control circuit and a control protection circuit. Through the high voltage supply electric leakage protection method and apparatus, when a leakage current is detected, the high voltage supply can be timely controlled to be disconnected and the electronic switch is controlled to be disconnected, so that a human body can be protected timely.