The invention discloses a route configuration method of an OSPF-SDN mixed network. The route configuration method comprises the steps that multiple historical traffic matrixes related to the network are acquired; the deployment positions of SDN nodes in the network are determined according to the historical traffic matrixes; the optimal weight configuration of the network is acquired according to the historical traffic matrixes; multiple SDN node-based distribution ratios are acquired according to the optimal weight configuration and the historical traffic matrixes; and real-time configuration is conducted on the network on the basis of the optimal weight configuration and the distribution ratios. According to the method of combining off-line OSPF weight optimization with on-line SDN distribution ratio optimization, optimization configuration on the mixed network described by multiple traffic matrixes is achieved, optimization of the highest link utilization rate of the network can be improved by 13%-42%, and the difference between the achieved highest link utilization rate of the network and the theoretical optimal solution is within 10%.