The invention belongs to the technical field of irradiation, and more specifically relates to an irradiation degradation method of aquatic product antibiotics. The irradiation degradation method comprises steps of cobalt-60gamma irradiation treatment and periodic forward and reverse current treatment. According to the irradiation degradation method, irradiation treatment is taken as the base, combination of periodic forward and reverse current treatment is adopted, so that on one hand, the relatively low irradiation absorbed dose is capable of reducing chloramphenicol residual quantity to 0.1g/kg, degrading chloramphenicol into three-order products completely, and on the other hand, yellowing of aquatic products after irradiation is not caused, no influence on aquatic product quality is caused, and obvious improvement is achieved.