The invention discloses a distribution protection coordination structure and device with a flexible interconnection device and a coordination method. Under the framework of coordination control, the fast state perception and alternating current side feeder line protection control device of the power electronic device of an alternating current-direct current flexible interconnection device is fully used to realize rapid fault location and fault removal, so as to realize rapid region fault self-healing in a full alternating current-direct current system. A GOOSE communication network based on region high-speed information exchange is provided. Global information high-speed communication of intelligent devices including a flexible direct current interconnection device in the same alternating current-direct current system is realized. Automatic rapid fault location and isolation of the protection device are realized according to pre-set conditions. Compared with the protection configuration method of a traditional power distribution system, the device has the advantages of faster fault handling speed and better coordination troubleshooting capability, and has a high application value.