The invention discloses an audio playing system based on a region distributed sound box, which comprises an audio source, audio control equipment, main sound boxes and a plurality of speakers, wherein the audio source and the audio control equipment are positioned at a center control end; the main sound boxes are positioned at terminals; the audio control equipment is connected with the audio source by an audio interface and a control interface, and is respectively connected with each main sound box positioned at the terminal by a center control end interface module through taking a coaxial line as a transmission line and adopting a star-shaped topological structure; the main sound boxes are connected with a plurality of auxiliary sound boxes to form multi-channel audio playing equipment; and three types of signals, i.e., an audio signal, a control signal and a power supply signal, are simultaneously transmitted in the coaxial line. The audio playing system disclosed by the invention is easy to arrange wires and convenient to construct; multi-channel audio playing is carried out; sound quality is excellent; user experience is good; audio data streaming is stable to transmit; anti-interference performance is high; influence of signal shaking of the audio playing system on the sound quality is avoided; and the audio playing system has wide application prospect.