The invention discloses a double-slug profile control agent for a low-permeability channel type reservoir and a use method of the profile control agent and relates to the technical of oil field applied chemistry. The profile control agent is injected into the low-permeability channel type reservoir in a double-slug manner, a front slug is mixed with sodium silicate, partially hydrolyzed polyacrylamide, sodium hexametaphosphate, sodium sulfite, salicylic acid and aluminum citrate, has the characteristics of low viscosity, high fluidity and high shear resistance and can plug high-permeability channels in the reservoir; a back slug is a compound surfactant and performs surfactant flooding on unplugged channels to reduce the content of residual oil in the reservoir, increase the oil layer moisture absorption index and eliminate the phenomenon that wax, colloid and asphaltene deposit in near-borehole zones. The heterogeneity of the reservoir is improved in the double-slug combination manner, the subsequent water flooding conformance factor is increased, and formation of dead oil zones of the low-permeability channel type reservoir is inhibited, so that the defects of low recovery efficiency, poor economic benefit and the like of traditional oil recovery methods for the low-permeability channel type reservoir are overcome.