The invention discloses a rich liquid ethylene glycol desalting device. The device comprises a three-phase separator, a rich liquid ethylene glycol buffer tank, a heat exchanger, a first cation exchange resin bed, a second cation exchange resin bed, a cation exchange resin regenerated liquid storage tank, a first anion exchange resin bed, a second anion exchange resin bed, an anion exchange resin regenerated liquid storage tank and a rectifying tower. High-solubility salt and low-solubility salt are separated simultaneously by selecting ion exchange resin with high selective exchange performance, the separation effect is better, after separation, the mass concentration of the low-solubility salt is lower than 1 mg/L, the mass concentration of the high-solubility salt is lower than 1 mg/L, and little energy is consumed during removal of salt ions in the rich liquid ethylene glycol in the method.