利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN107354136A 重组单纯疱疹病毒及其制备方法和应用 无效 - 撤回

重组单纯疱疹病毒及其制备方法和应用
摘要：
本发明涉及基因工程领域，公开了一种重组单纯疱疹病毒、所述重组单纯疱疹病毒的制备方法和应用。具体地，所述重组单纯疱疹病毒包括载体和编码至少两种细胞因子的外源基因，所述载体为缺失编码ICP34.5和ICP47的基因、以及可选择的缺失编码ICP6、TK和UNG的基因中的至少一种的单纯疱疹病毒，所述外源基因的插入位点为所述载体上缺失编码ICP34.5、ICP47、ICP6、TK和UNG的基因的位置中的至少一处。本发明提供的重组单纯疱疹病毒具有良好的抗肿瘤效果，并且使用后副反应小，具有良好的应用前景。
摘要（英）：

The invention relates to the field of gene engineering, and discloses a recombinant herpes simplex virus and a preparation method and applications thereof. Specifically, the recombinant herpes simplex virus comprises a carrier and an exogenous gene for coding at least two gene factors. The carrier is at least one of a herpes simplex virus with a gene with lost code ICP34.5 and ICP47 and a herpes simplex virus with a gene with selectively lost code ICP6, TK and UNG. The insertion site of exogenous gene is at least one of positions of lost code ICP34.5, ICP47, ICP6, TK, and UNG in the carrier. The provided recombinant herpes simplex virus has a good antitumor effect, little side effect, and good application prospect.

0/0