The embodiment of the invention provides a voice reduction method and device, a mobile terminal, and a computer readable storage medium. The method is used for the mobile terminal, and the mobile terminal is connected with an earphone. The method comprises the steps: collecting a first audio signal; receiving a second audio signal transmitted by the earphone; detecting whether the mobile terminal is shaded or not; extracting a target noise signal from the first audio signal and/or the second audio signal based on a detection result; carrying out the noise reduction of a third audio signal obtained by the mobile terminal through the target noise signal, and outputting a fourth audio signal. The third audio signal is an audio signal collected by the earphone or an audio signal to be transmitted to the earphone. According to the embodiment of the invention, the method achieves a purpose of dynamically selecting a proper noise reduction scheme according to the environment, improves the noise pickup precision, and improves the noise reduction effect.