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发明授权
CN107365300B 一种有效去除兰索拉唑粗品中杂质的方法 有权

一种有效去除兰索拉唑粗品中杂质的方法
摘要：
本发明公开了一种有效去除兰索拉唑粗品中杂质的方法。该方法是将兰索拉唑粗品转化为兰索拉唑盐后溶于有机混合溶剂，然后进行减压蒸馏，最后再转化为兰索拉唑析出。本发明方法利用了兰索拉唑盐比兰索拉唑稳定性更高的特点，兰索拉唑精制收率可以达到84.7％以上，而且可以有效去除兰索拉唑中的杂质，精制品中杂质A、杂质B、杂质C和杂质E的含量分别在0.011％、0.013％、0.012％0.015％以下，而杂质D则未检出。
摘要（英）：

The invention discloses a method for effectively removing impurities in lansoprazole crude products. The method includes converting the lansoprazole crude products into lansoprazole salt and then dissolving the lansoprazole salt in organic mixed solvents; carrying out reduced-pressure distillation; then carrying out conversion to obtain lansoprazole and dissolving out the lansoprazole. The method has the advantages that the characteristic of high stability of the lansoprazole salt as compared with the lansoprazole is utilized, and accordingly the lansoprazole refining yield can reach 84.7% at least; the impurities in the lansoprazole can be effectively removed, the contents of impurities A, impurities B, impurities C and impurities E in refined products are lower than 0.011%, 0.013%, 0.012% and 0.015%, and impurities D cannot be detected.

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