The invention discloses an electric power isolation control circuit comprising a voltage transformer isolation circuit, a resonance oscillation amplification circuit and a decoding circuit, wherein the voltage transformer isolation circuit is used for isolating the whole circuit from a 220 V alternating current power source, and the alternating current power source can be prevented from interfering with the whole circuit; the voltage transformer isolation circuit comprises a voltage transformer T1, an electric inductor L1 and an electric inductor L2; reactive power absorbed by the circuit is enabled to be zero via the resonance oscillation amplification circuit, and signals can be output after being amplified; the resonance oscillation amplification circuit comprises a resistor R10, an electric inductor L3, a capacitor C9 and a triode VT5. According to the electric power isolation control circuit, the voltage transformer isolation circuit is added on a 220 V alternating current end; fire hazards can be effectively prevented from being caused by lightning strokes, line aging and the like; the resonance oscillation amplification circuit is added at a plurality parts of the circuit, reactive compensation for circuit consumption can be reduced, energy can be saved, and environment protection can be achieved.