The invention discloses an efficient compound desulfurizing decarbonizing solvent which comprises the following components by weight percent: 60-85% of serotonin, 3-20% of activating agent, 10-30% of physical solvent, 0.01-0.2% of de-foaming agent, 0.5-2% of antioxidant and 0.5-2% of corrosion inhibitor. The efficient compound desulfurizing decarbonizing solvent provided by the invention is capable of simultaneously removing acidic gas and organic sulfide in the mixed gas, has the advantages of high acid gas load, low sulfur content in purified gas, stable solvent performance, recycling property, no corrosion to equipment, and the like, can be used for removing the acidic gas and organic sulfide in the gases, such as, natural gas, petroleum refinery gas, synthesis gas and liquefied petroleum gas, and has an excellent popularizing effect.