The invention discloses a monowheel manual die-cutting machine comprising a workbench, a crossbeam, support rods, an upper pressing plate, an eccentric shaft, an eccentric wheel, a pressure shaft, a reset spring and a distance adjusting rod. The bottom ends of the two support rods are fixed to the two ends of the workbench correspondingly. The support rods are sleeved with the crossbeam fixed to the support rods in a threaded mode, and the crossbeam can slide up and down along the support rods. The upper pressing plate is located between the crossbeam and the workbench. The pressure shaft penetrates through the crossbeam, and the bottom end of the pressure shaft is fixed to the upper pressing plate. The eccentric wheel is placed on an arc-shaped bracket fixed to the top end of the pressure shaft. The part, located above the crossbeam, of the pressure shaft is sleeved with the reset spring. The eccentric shaft is sleeved with the eccentric wheel and is fixed to the crossbeam through the distance adjusting rod. The monowheel manual die-cutting machine can achieve die forming of a small area, the whole monowheel manual die-cutting machine can be adjusted conveniently when used, and use operation is safe. Work efficiency of die board cutting is improved.