The invention discloses an in-mould injection molding and coating process. The process includes steps: performing injection molding of a thermoplastic base material, wherein a mould structurally comprises an injection molding side front mould, common rear moulds and a coating side front mould, and the common rear moulds are mounted on two sides of a center rotary mould plate; after mould closing, injecting the thermoplastic base material into a corresponding cavity by an injection molding unit; maintaining the pressure and cooling; opening the mould, enabling the center rotary mould plate to drive the common rear moulds and the thermoplastic base material to rotate by 180 degrees, and closing the mould; enabling a coating mould and an injection molding mould to perform in-mould reaction coating and injection molding at the same time, injecting a coating material into a corresponding cavity by a mixing head, and injecting the thermoplastic base material into the corresponding cavity by the injection molding unit; subjecting the coating material to reaction solidification in the coating mould while subjecting the thermoplastic base material to pressure maintaining and cooling in the injection molding mould; opening the mould to take out a coated product; rotating the center rotary mould plate by 180 degrees to close the mould. By the in-mould injection molding and coating process, injection molding and in-mould reaction injection molding polyurethane paint coating are realized on a same machine, and technical simplicity is realized.