The invention provides a high-seepage sandstone oil reservoir compound polymer type profile control agent and a use method thereof, and relates to field of oil field application chemistry. A compound polymer is formed by mixing three kinds of partially hydrolyzed polyacrylamide with different molecular masses; the compound polymer and additives are mixed for forming the profile control agent; two kinds of profile control agent slugs with different characteristics are prepared through regulating the proportion of the partially hydrolyzed polyacrylamide and the additives. In the implementation process, high-seepage zones and big pore passages of a high-seepage sandstone oil reservoir are sealed and plugged through a prepositive slug; the profile control is implemented by a postpositive slug; the problems of low polymer flooding yield, invalid polymer flooding circulation, clay expansion, dead oil zone generation inhibition and the like of a conventional high-seepage sandstone oil reservoir are solved. The profile control agent has the advantages that the preparation method is simple; before the curing, the viscosity is low; the injection is easy; the adaption to preparation water with the mineralization degree being 500mg/L to 35000mg/L can be realized; in addition, the raw materials are cheap and can be easily obtained.