The invention relates to a self-controlled protector tolerant to high voltage and a manufacturing method thereof and belongs to self-controlled protection components and devices for electronic products. The self-controlled protector tolerant to high voltage is especially suitable for self-controlled protection components and devices for lithium ion battery protection and comprises a ceramic substrate, electrodes, an insulating layer and main conductive loop, wherein the ceramic substrate is rectangular, the electrodes 1, 2, 3 and 4 are symmetrically arranged on four sides of the ceramic substrate, a pair of opposite electrodes is connected with at least one heating layer, the insulating layer is arranged on the heating layer, and the insulating layer is coated with an electrode layer. At least one blocking layer is arranged on other pair of electrodes, the electrode layer and the blocking layer are connected with the main conductive loop in a welding or printing and sintering mode, and an upper cover is bonded above the ceramic substrate after the main conductive loop is coated with a fluxing agent. The self-controlled protector tolerant to high voltage has functions of a conventional large-current fuse wire and meanwhile has a function of controlling fusing of the main conductive loop itself.