The invention discloses a manually operated wheelchair mistaken sliding prevention locking device, and relates to the field of machines and electronics. In order to achieve the purpose, the manually operated wheelchair mistaken sliding prevention locking device is mainly composed of a left side near wheel opening and closing device, a right side near wheel opening and closing device, an electromagnet, a permanent electromagnet, a magnetic suction brake mechanism, a parking mechanism and a storage battery capable of being charged repeatedly, wherein a left side pressing plate or a right side pressing plate further comprises a mechanical circuit opening and closing device, when a left hand or a right hand of a wheelchair user is naturally placed on the left pressing plate or the right pressing plate, due to the manual hand pressure effect, the circuit opening and closing device is in the closing state, the device can be normally used by hand to move forwards, and no obstruction exists. The manually operated wheelchair mistaken sliding prevention locking device has the advantage that mistaken sliding of the wheelchair body can be automatically avoided by placing the hands.