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发明授权
CN107400412B 一种聚酯碳酸酯酸酐3D打印生物墨水及3D打印方法 有权

一种聚酯碳酸酯酸酐3D打印生物墨水及3D打印方法
摘要：
一种表面降解型聚酯碳酸酯酸酐3D打印生物墨水及3D打印方法，所述3D打印生物墨水由一种凝胶墨水和一种支架墨水构成，所述凝胶墨水由水凝胶和生物细胞构成，所述水凝胶包括具有温度响应性的PLGA‑PEG‑PLGA三嵌段共聚物，所述支架墨水为具有表面降解特性的聚酯碳酸酯酸酐共聚物(P(LLA‑TMC‑SA)共聚物)。本发明利用上述3D打印生物墨水的温敏性以及可表面降解特性，针对3D生物打印支架体内降解过程中结构可控维持的需求，采用多组分材料梯度打印方式以同轴管形式打印获得含有生物细胞的具备可控表面降解支架支撑的模型，并且可以获得多孔结构的营养和代谢通道，有利于通过3D打印获得更大更厚的组织结构。
摘要（英）：

The invention discloses temperature-responsive and degradable 3D printing bio-ink and a 3D printing method. The 3D printing bio-ink is composed of a temperature-responsive hydrogel and biological cells, wherein the hydrogel is prepared from a PLGA-PEG-PLGA triblock copolymer with the temperature responsibility and other additives through mixing in a certain ratio. The critical phase transformation temperature range of the PLGA-PEG-PLGA triblock copolymer with the temperature responsibility is 20-33 DEG C and the PLGA-PEG-PLGA triblock copolymer has the characteristic of being cured into gel at the human body temperature of 37 DEG C, so that the 3D printing bio-ink has the same temperature-responsive and degradable characteristics. The pre-condensed bio-ink is prepared before printing by use of the temperature-responsive and degradable characteristics of the 3D printing bio-ink, rapid heating and dewatering are performed after a model is slowly frozen after printing, a porous structural model containing the biological cells can be formed, nutrition and metabolic channels with porous structures can be obtained, and larger and thicker tissue structures are advantageously obtained through 3D printing.

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